Abstract: The Madao lead-zinc-silver deposit is located in the northern foot of the Dabie Mountains, about 18 km southeast of the Biyang County. It is located in the Liushan rock formation on the north wing of the north Qinling fold belt of the East Qinling orogenic belt. The ore body is divided into layered and reticular. The layered ore body is distributed in the volcanic debris and hydrothermal sedimentary altered rock with the basic volcanic rock as the floor, which belongs to the overflow phase. The stockwork ore body is distributed in the altered rock tube, which belongs to the volcanic neck facies. Both of them form a 'T' shape in space and form a complete volcanic mechanism model in space, which belongs to the VMS deposit. The exploration work adopts soil geochemical survey and geophysical electrical method to measure the effect is good, the surface soil Au, Ag, Pb and Zn in the mining area are strongly enriched and distributed, and the deep ore body is characterized by medium and high resistivity and high polarizability distribution. This paper summarizes the geophysical and geochemical characteristics of the deposit, establishes a prospecting model, and provides a reference for the search for similar deposits in the region.