Huayangchuan uranium is a polymetallic deposit of uranium and niobium associated with lead and rare earth elements in the west of Xiaoqinling tectonic belt on the southern margin of North China craton. The uranium deposits have various types and complex genesis, and have good uranium metallogenic conditions and resource potential. Because Huayangchuan area is located on the north slope of Qinling Mountains, with steep terrain and serious coverage, it is very difficult to carry out surface prospecting. The combination of hydrochemical method and ground gamma survey were used to delineate mineralized bodies in the past, the exploration effect is poor and the efficiency is low due to the topography and vegetation. Based on the previous research results and existing geological data, this study adopts airborne gamma spectrum measurement to quickly find anomalies, activated carbon and pit gamma measurement to accurately identify the mineralized zone, special geological mapping with different scale to carry out mineralized body inspection, supplemented by remote sensing interpretation, IP sounding and magnetic measurement, and finally passes the verification of exploration engineering, a combination of technical methods suitable for the rapid positioning of hard rock type uranium deposits in the coverage area of high mountains and valleys in Huayangchuan area is explored. Through the prospecting practice, we have selected 7 favorable areas, 3 target areas and 6 important clues for ore prospecting, and a large number of uranium deposits (or prospecting target area) have been found in Huangjiagou area outside Huayangchuan uranium mining area. This paper systematically summarizes the various uranium prospecting techniques and methods adopted, so as to provide experience and reference for uranium prospecting in similar areas in the future.