Abstract: In recent years, mineral exploration of Lithium(Li)-Beryllium(Be) deposit in Dahongliutan area of Karakoram, Xinjiang, has been greatly improved and showed good metallogenic potential. However, because of the high cold and deep cutting environment, the mineral prospecting work in this area is hard whereas urgently needs to develop. Our group has played a positive role in the exploration of pegmatite type Li-Be deposit by using high-resolution, multi-spectral remote sensing data and hyperspectral technology in this area, and several large Li-Be deposits, such as 505, 507, south fulugou 1^# and south fulugou 2^# have been discovered. In this study, we carried out the ground spectral testing of rock and ore deposits in pegmatite type lithium deposits in this area. The spectral characteristics of bearing ore stratum, rock mass, ore bearing pegmatite and ore without pegmatite of different lithology are systematically compared. The mineral assemblages are calculated and analyzed. It is considered that the lithium-bearing pegmatite in the ore bearing pegmatite is mainly composed of spodumene and lepidolite, and a small amount of lithium chlorite, with high reflectivity and shows strong Al-OH absorption peak. Mg-OH absorption peak is also developed under the influence of the later hydrothermal alteration, which together constitute the symbolic remote sensing anomaly assemblage of ore bearing pegmatite in the area. Basing on the domestic hyperspectral remote sensing satellite data, the above anomaly combinations were extracted by matching filtering method, and 7 prospecting targets were delineated, which is important for the further lithium beryllium prospecting in this area.