Abstract: Mesozoic era, as a important phase of structure transformation during the crustal evolution of the eastern Tianshan-Beishan area, was a important metallization period of hypogene deposits when some important deposits and some important mineral commodities had been formed. The metallization ages of indosinian hypogene deposits ranged from 250Ma to 210Ma, when some mineral commodities had been formed such as Tungsten, Molybdenum, aurum, Lead, Znc, Niobium, Tantalum, Fluorspar, Rare earths, Granite, Argent, Rhenium, Iron and Gangquarz. The metallization ages of Yanshan hypogene deposits ranged from 180Ma to 150Ma, when some mineral commodities had been formed such as Tungsten, Niobium, Tantalum, Lead, Znc, Copper, Aurum,Stibimum, Hydragyrum, Troilite, Fluorspar and Gangquarz. These ore deposits extended all over the four metalogenic belts of the eastern Tianshants extended a. But the ones were the most in the Dunhuang metallogenic province. The mineralization was mainly in connection with the magmatic activity and the tectonic action. Most deposits were obviously dominated by the magmatic bodies and the faults, and main ore bodies occurred inside of the magmatic bodies or the clastic rock or carbonztite. It was not only the result of intraplate tectonic action, but also the far-ranging reflection of the magmatic intrusion which originated from the interlocking of Paleotecthys and Mongolia-Ehuocike ocean.